Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy.Herein, an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed, which can dilate vessle and improve the drug penetration by in situ releasing nitric oxide (NO).Briefly, S-nitroso-glutathione (GSNO
Hyponatraemia is the most commonly encountered electrolyte disturbance in neurological high dependency and intensive care units.Cerebral salt wasting (CSW) is the most elusive and challenging of the causes of hyponatraemia, and it is vital to distinguish it from the more familiar syndrome of inappropriate Bandages antidiuretic hormone (SIADH).Manag
Pancreatic cancer has the worst prognosis and lowest survival rate among all cancers.Pancreatic cancer cells are highly metabolically active and typically reprogrammed for aberrant glucose metabolism; thus they respond poorly to therapeutic modalities.It is highly imperative to understand mechanisms that are responsible for high glucose metabolism
Brachycephalic dogs are not only affected by brachycephalic obstructive airway syndrome (BOAS), but are also frequently referred to veterinary dermatologists for skin conditions, with English bulldogs and pugs particularly over-represented.Some skin diseases, such as skin fold dermatitis, are directly associated with the abnormal anatomic conformat